Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
نویسندگان
چکیده
Hydrotalcite-type materials, or layered double hydroxide (LDH), are very promising in applying slow-release drug systems through ion exchange and delamination characteristics at acidic pH. In this paper, Zn/Al LDHs 2:1 3:1 molar ratios intercalated with the ibuprofen (IBU) were added to chitosan/alginate membranes. release tests, an increase solubility of membranes could be observed, percentage is lower than free samples. The following percentages obtained: 15.48% 17.5% water, 23.22% 26.25% PBS buffer solution, respectively, for membrane samples containing Zn2Al-IBU Zn3Al-IBU LDHs. Thus, synthesized hybrid (chitosan/alginate-LDH-IBU) application as resorbable bone grafting release.
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ژورنال
عنوان ژورنال: Materials Research-ibero-american Journal of Materials
سال: 2021
ISSN: ['1980-5373', '1516-1439']
DOI: https://doi.org/10.1590/1980-5373-mr-2021-0312